Timeline of Published Research Studies

April 2025

Gupta Program significantly more effective than standard medication in improving symptoms of fibromyalgia

In an independent randomized controlled trial on Fibromyalgia patients, the Gupta Program was compared to a control. After 12 weeks, the Gupta Program group significantly improved across a range of measures compared to the control, with large to very large effect sizes.

AIR participants showed significant improvements compared to a control taking Pregablin:

  • Fibro (FIQ) Score

    54%reduction(9% in control)
  • Sleep Disturbance

    63%reduction(15% in control)
  • Pain

    50%reduction(8% in control)
  • Depression

    49%reduction(8% in control)
  • Cognitive Function

    16%improvement(4% in control)
Read more »
April 2025
June 2024

Gupta Program significantly improves sleep, depressive symptoms, cognitive decline, and improves working memory in older adults

In an independent randomized controlled trial, the Gupta Program plus exercise was compared to a control. After 12 weeks, the Gupta Program group significantly improved compared to the control, with large to very large effect sizes.

AIR participants plus exercise showed significant improvement across 4 different measures:

  • Depressive Symptoms

    37%reduction
  • Improvement in Sleep

    56%improvement
  • Working Memory

    26%improvement
  • Emotional Dysregulation

    37%reduction
View Published Paper »
June 2024
February 2024

Gupta Program Increases Health & Functioning for 14 Different Chronic Conditions

An international audit conducted by an independent research firm evaluated the impact of the Gupta Program on a wide range of chronic conditions. After more than three months of consistent use, participants reported:

  • Significant improvements in overall health and functioning across 14 out of 16 conditions assessed

  • Meaningful positive trends approaching significance for the remaining two conditions

Positive symptom shifts after three months of practice:

  • ME/CFS

    70%improvementn=139
  • FIBROMYALGIA

    62%improvementn=52
  • LONG COVID

    84%improvementn=30
  • MOLD

    67%improvementn=40
  • MCS

    85%improvementn=53
  • MCAS

    52%improvementn=56
  • CIRS

    60%improvementn=19
  • EHS

    82%improvementn=18
  • ANXIETY

    68%improvementn=121
  • PANIC

    100%improvementn=34
  • BURNOUT

    76%improvementn=33
  • IBS

    64%improvementn=66
  • FOOD SENSITIVITIES

    56%improvementn=97
  • SIBO

    46%improvementn=30
  • PAIN

    56%improvementn=26
  • LYME

    116%improvementn=27
read more »
February 2024
July 2023

Gupta Program Reduces Long COVID Fatigue

A 3-month randomised controlled trial evaluating the Gupta Program in individuals with Long COVID demonstrated significant clinical improvements. Participants following the Gupta Program experienced:

  • A substantial reduction in fatigue

  • Significantly increased energy levels

  • Greater improvement compared to a structurally similar wellness program

These benefits suggest that the Gupta Program may offer enhanced outcomes beyond standard lifestyle-based interventions, providing a uniquely effective approach for those navigating post-viral fatigue syndromes.

Symptom improvement after 3+ months:

  • Fatigue

    4XReductionCompared to the wellness program (MFI)
  • Increasing Energy

    2XImprovementCompared to a wellness program (SF36)
  • Energy Level

    97%Improvement47% in control group
Read More »
July 2023
October 2020

Gupta Program Reduces Fibromyalgia Symptoms in just 8 weeks

In an 8-week randomised controlled trial involving individuals with Fibromyalgia, the Gupta Program led to significant reductions in symptom severity and improvements in overall health. These outcomes were substantially greater than those achieved by participants following a structurally similar wellness program.

  • Notable decrease in symptom severity

  • Outcomes that surpassed those typically seen with standard wellness approaches

Symptom improvement in 8 weeks:

  • Fibro (FIQ) Scores

    37%reduction0% in control
  • Perceived Health (EQ-VAS)

    47%improvement16% in control
  • Pain Catastrophizing

    46%reduction9% in control
  • Depression (HADS-B)

    41%reduction6% in control
  • Anxiety (HADS-A)

    45%reduction15% in control
Read More »
October 2020
April 2012

Gupta Program Increases Health & Energy for ME/CFS & Fibromyalgia Patients

A 3-month randomised controlled trial assessed the Gupta Program’s impact on individuals with ME/CFS or Fibromyalgia. The results showed marked improvements in physical health and energy, alongside significant reductions in pain, fatigue, and overall symptom distress. These changes were far more substantial than those seen in participants receiving standard medical care.

  • Noticeable gains in energy, pain levels, and day-to-day functioning

  • Clinically significant reductions in fatigue, pain, and symptom-related distress

  • Progress well beyond what is typically observed with standard care alone

Symptom improvement after 3+ months:

  • Physical Health

    211%improvement-5% in control
  • Energy

    63%improvement-3% in control
  • Fibro (FIQ)

    24%reduction3% in control
  • Pain

    32%reduction9% in control
View Published Paper »
April 2012
September 2010

Gupta Program Improves Health & Functioning for ME/CFS Patients

A clinical audit of individuals with ME/CFS provided early support for the Gupta Program’s foundational approach. The results were striking: virtually all participants reported noticeable improvements in their health and wellbeing.

  • Widespread symptom improvement across participants

  • Two-thirds reported reaching 80–100% functional recovery

Results After 12 Months of Using The Gupta Program:

  • Patients Reporting

    93%improvement
  • Full Functioning

    63%improvement
View Published Paper »
September 2010
May 2022

Foundational Hypothesis for the Gupta Program

After years of living with ME/CFS and deeply researching its mechanisms, Ashok Gupta developed the foundation for what would become the Gupta Program—and used it to support his own recovery. While the program has evolved and expanded over the past two decades, its core hypothesis has remained largely unchanged.

This foundational understanding continues to guide the program today. For many participants, it offers not only clarity on the nature of their condition, but also a hopeful and empowering path forward.

View Published Paper »
May 2022

Meet the Research Team

These results are possible thanks to dedicated professionals who believe in a gentle, neuroscience-based approach to healing.

  • Kelly Scotti

    Clinical Research Consultant - Team Lead

    Kelly is a neurodiverse Clinical Research Consultant with over 30 years of experience managing clinical trials across pharmaceutical and biotech settings.

    She’s also a certified coach and yoga teacher, supporting neurodivergent women in grounding, resetting, and stepping into their purpose. After using the Gupta Program to manage symptoms from Lyme disease, ADHD, and perimenopause,

    Kelly was inspired to contribute her expertise to the team. Today, she leads research efforts to build the program’s scientific foundation and bring neuroplasticity-based healing into wider clinical recognition.

    kelly scotti circle
  • Lauren Witt

    Fundraising Director, Chronic Conditions Research Fund (CCRF)

    Lauren is a seasoned nonprofit strategist with a background in public health and over a decade of experience in grant writing and development.

    She leads fundraising efforts at CCRF to support research into chronic conditions and also manages grant programs for STEM education.

    Having contributed to national health studies and awareness campaigns, Lauren is passionate about building partnerships and securing sustainable funding that helps expand access to evidence-based, patient-focused care.

    sophie
  • Sophie N

    Research Assistant

    Sophie is a research assistant and psychotherapist. With her background in psychology, sociology, and yoga training, she brings an awareness of the holistic nature of healing through mind, body, and spirit.

    Sophie used brain retraining to aid in her own recovery from complex disease. With her belief in the power of neuroplasticity from personal healing experiences, Sophie is passionate about making brain retraining an integral part of medical recovery through clinical research studies.

    sophie
  • Elizabeth McNabb

    Lead Coach for Clinical Trials

    Elizabeth is a scientist and Gupta Program Coach with international experience in healthcare and wellbeing.

    Her personal journey through fatigue, sensitivities, pain, and Ehlers-Danlos Syndrome led her to the Gupta Program, where she finally found lasting insight and relief. She now uses the program to manage her symptoms and live a full, active life. Inspired by her own recovery,

    Elizabeth supports clinical trial participants with compassion and clarity—helping others regain agency and hope on their path to healing.

    elizabeth circle
  • Building the Future of Recovery, Together

    These early findings are a meaningful step forward, but the journey continues. We’re committed to ongoing research, refinement, and real-world support. If you’re passionate about contributing to this work or sharing your experience, we’d love to connect.