Amygdala and Insula Retraining

A process for healing chronic conditions based on 20 years of research and experience

I’m excited to share with you my explanation of these conditions.

Which I call "Neuro-Immune Conditioned Syndromes (NICS)." I have spent the last twenty years researching and refining this explanation. It is based on my medical paper which was published in a medical journal in 2002.

The paper was first published online in 2000. Normally this therapy was only available to a relatively small number of patients that I am able to see at my clinic, but now everyone in the world can experience its powerful effects.

Amygdala and Insula Retraining Supports the Healing of These and Other Related Conditions

Randomized Controlled Trial Regarding Amygdala and Insula Retraining Published in the Journal of Clinical Medicine

It is estimated that at least 2% to 5% of the population suffer from this complex pain condition in some form, and until now there has been a lack of effective treatments. The novel Neuroplasticity program known as “Amygdala and Insula Retraining” was combined with Mindfulness to create 'MAIR', also known as the Gupta Program, and was tested for 8 weeks against a control group engaging in an equivalent amount of relaxation techniques.

The results found that after just an 8 week intervention, the MAIR group had significantly greater reductions in symptoms and pain, and increases in overall health, compared to the control group. The Gupta Program is normally a minimum 6 month intervention, so we expect even better results when used for a longer period. These are the key results from the 8-week study:


Further Ground-Breaking Neurological Research Supporting the "Amygdala and Insula Retraining" (AIR)

I wanted to share further ground-breaking neurological research supporting the "Amygdala and Insula Retraining" (AIR) processes within the Gupta Program. In this latest research, it is stated that it is now high likely that conditioning of the immune system occurs in the insula. Within the Gupta Program, we believe that it is the same process responsible for Long Covid, in addition to ME/CFS, Fibromyalgia, Mold illness, MCAS, MCS and a whole host of similar conditions.

If you wish to read the original medical article, a summary is available here: 

We at the Gupta Program are engaging in continuous scientific research to find the best solutions for chronic illnesses to support your healing. And I hope that this article further reinforces your belief in the Gupta Program, and helps you recommit each day to engaging with the techniques.

If you know any medical Doctors or researchers who would like to partner with us in any way, please do contact our Clinical Research Director Alex Bratty, on, or visit our research team page

Please Watch These Videos for an Explanation of What Causes Your Conditions

My Amygdala and Insula Hypothesis

My medical research seems to indicate that these conditions are neurological in nature, and may be caused by abnormalities in a brain structure called the ‘amygdala,’ and the ‘insula’.

One of the amygdala’s roles is to protect the body from potential threats.

  • Research has traditionally focused on physiological or emotional threats,
  • Whereas recent research is showing that the amygdala and insula are involved in protection mechanisms and conditioned immune responses related to chemical and immunological threats as well. See a summary of this novel research here. 

This hypothesis serves as a potential unifying model for the various observations in patients. I published my hypothesis in the journal Medical Hypotheses in 2002.

Please download our new medical 3 pager and share it with your doctors and health professionals.

A Basic Explanation of the Medical Paper (in Layman’s Terms)

Precipitating Factors


Pre-disposing Factors, e.g. Genetic and Environmental Risk Factors (1)

Right at the top, let’s start with the predisposing factors to developing these illnesses – i.e., the risk factors. These may include genetic factors and environmental factors yet to be fully determined.

Then there are two other precipitating factors that contribute to these illnesses developing in someone.

Triggers: Acute Psychological Stress (2) & Viral, Bacterial, or Other Triggers (3)

The start of the illness is often accompanied by psychological or physical stress, as well as some kind of acute physical illness.


In the case of ME/CFS, that physical illness might be a particularly difficult virus or bacterial infection (e.g., Glandular Fever, gut enteroviruses, etc.), or another kind of illness.


In fibromyalgia, the physical trauma may be an accident, or ongoing chronic pain in a part of the body.


In MCS, the trigger may be heavy exposure to a toxin.


In IBS, it may be food poisoning or a similar traumatic event for the gut.

Other Conditions

For other conditions, they relate to the original triggering injury or infection.

There will be crossovers in symptoms between these conditions, according to the theory. The theory predicts that the pattern of symptoms in the body will be different, but that the underlying cause may be the same. The theory still holds if there is a gradual onset versus a specific onset (see medical paper for further details.)

Gulf War Syndrome may represent a combination of all three illnesses to varying degrees, as at the time there was exposure to immunizations, toxins, and physiological stresses all at the same time.

Conditioning In The Amygdala and Insula

The combination of these precipitating factors changes the circuitry of the amygdala and the insula, making it continually over-stimulate the body (4).


During the trauma:

  1. The amygdala learns to be hyper-reactive to any symptoms detected in the body, in association with the ‘insula’ which can no longer process incoming signals and overstimulates the brain and body

2. This conditioning happens unconsciously without a person actually realizing it is happening.

Chronic Stimulation of the Arousal System

From then on, the amygdala and insula continually over-stimulates the sympathetic nervous system directly (5), as well as aspects of the immune system.

1) It over-stimulates the hypothalamus and the whole HPA (Hypothalamic-Pituitary-Adrenal) Axis, which subsequently downgrades as a result, making it difficult for the body to respond to stress.

2) The amygdala also over-stimulates the whole brain, keeping many brain circuits in a state of hyper-arousal. This adversely affects the levels of neurotransmitters in the brain, including serotonin and dopamine.

3) There may also be conditioning in the immune system. This means that aspects of the immune system are inappropriately re-triggered in a unique pattern individual to each patient. This can cause excessive inflammation throughout the body, as well as neuroinflammation in the brain.

4) Finally, this over-stimulation causes higher levels of oxidative stress in the body, and a compromised immune system.

A continual unremitting stimulation can cause symptoms which can severely affect every single organ and system in the body, including the endocrine (hormonal) system, and the immune system.

Furthermore, continual stimulation can cause secondary effects in the body, which then lead researchers to think that those physical observations are the cause of the condition, whereas they are simply symptoms of a deeper underlying brain abnormality.

Symptoms and Secondary Illness Cycles


Hyper-arousal of the body then causes the symptoms (6) and creates Secondary Illness Cycles (7).

Over-stimulation can cause adaptation in receptors so that systems are down-regulated, or certain systems may simply exhaust due to over-stimulation, as is the case with the adrenal glands. Nitric oxide levels may rise (as per the observations of Professor Martin Pall), which can cause a whole host of secondary effects and symptoms in the body, including mitochondria dysfunction, perpetuating the entire vicious circle. Because the immune system is responding inappropriately, opportunistic viruses such as HHV-6 have the opportunity to flourish, increasing symptoms.

Finally, at (7), secondary illnesses such as allergies and chemical sensitivities can occur due to the hypersensitivity of the entire system.

Sympathetic over-activity means that sleep rhythms are affected, so the restorative “delta” sleep required for bodily repair is not effective. This has also been shown in Post Traumatic Stress Disorder, an illness where the amygdala has also been heavily implicated. This causes a patient to feel unrefreshed the next morning, causing severe exhaustion, and contributing to pain in fibromyalgia.

Perpetuating Factors

These symptoms are detected by the sensory thalamus/cortex and the insula cortex – the parts of the brain that receive incoming information from the senses (8).

And to complete the cycle, incoming signals are magnified by the amygdala, which keeps the brain and nervous system in a state of hyper arousal (9).

* The insula may be involved in interpreting the emotional meaning of the symptoms, and passing that representation on to the amygdala. The Insula also retriggers aspects of the immune system due to the inappropriate conditioning

* At 9, the amygdala is traumatized by any symptoms that it detects in the body, and instantly re-stimulates bodily systems at 4 again.

Note that this central nervous system sensitivity (and resultant abnormal sensory processing causing heightened pain awareness) is gradually becoming a more accepted hypothetical model in fibromyalgia. This then perpetuates into the vicious circle as in the diagram.

Factors Determining Symptoms & Severity

If the circle becomes particularly vicious, a patient can become bed-bound. If the cycle is milder, the patient may be able to function to a varying degree. The symptoms in each patient will depend on three factors:


1. Severity

The severity of the conditioning effects in the amygdala, insula, and associated brain structures.


2. Specificity

The specificity of the conditioning; that is, what symptoms and what reactions were going on in the body at the time of the original trauma.


3. Timing

The specific timing of the trauma although symptoms can change over time.

Due to the secondary effects of the condition on the body, food intolerances can develop, as well as general sensitivities. This is because when the brain and body are on high alert, the amygdala (in association with other brain structures) is prone to learning new responses to stimuli it would not normally care about.

When the sympathetic system is aroused, digestive and detoxification systems are turned down or switched off, which may explain why many patients complain of feeling “toxic” inside.

A patient will also find that stress can exacerbate the symptoms – simply because it “speeds up” the vicious circle, and the body does not have sufficient resources to deal with that stress. The stress can be mental, emotional or physical.

With some patients, the conditioning effects are not particularly severe, which is why some patients seem to regain their health through general changes in lifestyle. For others, the conditioning in the brain is severe and causes chronic long term illness.

How The Symptoms of These Conditions Are Created

Learn more the range of physical, cognitive and emotional symptoms that those with ME/CFS, fibromyalgia, and associated illnesses may experience – explaining how they may be products of amygdala hyper-sensitization.

The Basic Concepts of Retraining The Amygdala and Insula

I wish to emphasize that I believe ME/CFS, fibromyalgia and MCS are real physical conditions, and are in no way psychological. The sensitivity conditioning mainly occurs unconsciously.

Currently, I do not believe that there are any pharmaceuticals which could target such a specific reaction in the brain. Most pharmaceuticals or supplements target the symptoms rather than the underlying cause. If the conditioning effects are mild, successful treatment of symptoms may bring full recovery, but in the majority of cases, this will probably not occur.

The unconscious brain reaction involved in amygdala and insula dysfunction is not normally under a patient’s control, but I believe that some novel “brain retraining” techniques derived from NLP (Neuro-Linguistic Programming), breathing, meditation techniques, and others, can target the reaction and control the amygdala. The techniques are highly specialized, and do not fit under any one category, which is why I refer to them as “Amygdala & Insula Retraining.”

Luckily the amygdala and insula constantly communicates with other parts of the brain, and that’s where retraining can take place.

In animal models, it is understood that the amygdala can be controlled with new neurons being formed, connecting from the pre-frontal cortex to the amygdala/insula, to subdue and control its reactions. Also strengthening the ability of the insula and anterior cingulate to regulate and inhibit reactivity in the brain (the ‘inhibition mechanisms’)


Some studies have shown that patients with ME/CFS have lower grey matter volume in this part of the brain (pre-frontal cortex), as well as excessive delta wave activity in the prefrontal cortex.


Other studies have shown that regular meditation can increase the volume of this part of the brain, showing that “brain” exercises can alter the structure of the brain.

Amygdala & Insula Retraining is designed to strengthen the prefrontal cortex and restore inhibitory mechanisms in the insula, anterior cingulate and other associated structures. All the Amygdala & Insula Retraining techniques are now available as an interactive online Neuroplasticity and Holistic Health program

How We Can Help You Get Your Life Back From The Condition

Get Immediate Access To Revolutionary Neuroplasticity Techniques Personally designed by Ashok, based on his 20 plus years of experience and research. PLUS a free 12- Week Webinar Series.


An Online Neuroplasticity 'Brain Retraining' Program

15 Brand new interactive video sessions online hot in the stunning mountains of Switzerland. 


The Latest Scientifically-Backed Holistic Advice

On topics such as diet, sleep, nutrition, mindfulness and pacing


12 Weeks of Group Coaching Webinars directly with Ashok

Get motivation & support throughout every step of your healing journey and have your questions answered directly by Ashok.



An Extensive Collection of Supporting Materials

You will receive a Manual and Mind Map in the post. Online there are numerous supporting audio exercises and meditations. These easy to access resources will help deepen your recovery further.


WorldWide Gupta Program Coaches

Access to trained Gupta Program Coaches to tailor the program to your needs


A Positive Online Healing Community

Full of like-minded individuals dedicated to health to help to support you through your recovery


Regular Newsletters Updating With New Information

We send regular newsletters to members that contain the latest healing content.


Optional USB Flash Drive

Containing all the Videos, Meditations and Audio Exercises that you can play without the need for an internet connection, and that you can keep forever.


Money-Back Guarantee 

We offer a one-year Money-Back Guarantee for your peace of mind, no questions asked.

Get a 12-Week Webinar Series Included in your Gupta Program v5.0 Purchase Today

When you invest in the Gupta Program v5.0, not only get immediate access to the revolutionary neuroplasticity and holistic health system, you also receive a free 12- Week Webinar Series (worth $119).


Gupta Program Mini Course


Sign up to access our first 3 sessions for free including videos about how to recover and access to our Member's Area.

Over the next 28 days get a sneak-peek into the revolutionary techniques of the Gupta Program, and learn the science behind how the expertly crafted combination of neuroplasticity & lifestyle changes can help support your healing.

If you then go on to invest in full membership you will be granted access to a 12-Week webinar series as part of your purchase.


Subscription to the Online Course + Manual + 12 Week Coaching Webinar Series


You will receive all of the following:

  • 15 Interactive Video Sessions online shot in the stunning mountains of Switzerland
  • Numerous Audio Exercises and Meditations
  • 12 Weeks of Coaching Webinars directly with Ashok, and you can ask questions
  • Accompanying Manual and Floor Chart sent in the post
  • Direct access to our healing private Facebook group
  • Regular newsletters updating with new information
  • A full one-year Money-Back Guarantee

Subscription to the Online Course + Manual + 12 Week Coaching Webinar Series + USB


Get everything that is included in the standard package PLUS a USB drive which contains all the Videos, Meditations and Audio Exercises that you can play without the need for an internet connection, and that you can keep forever. 

This option is particularly useful if you don't want to rely on internet access to use the Program or if you have Electrical Sensitivities. 



We Offer A One-Year Money-Back Guarantee For Your Peace of Mind

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If you notice no improvement after using the program for 6 months, you can return it for a refund, no questions asked.

We are so convinced that you will benefit if you commit to our program, that you have up to a year to trial the amazing brain retraining exercises, and you can return the program if it does not benefit you.

Therefore you have nothing to lose by seeing if this approach works for you and brings you the healing that you deserve. Thousands before you have taken this path!

Real Retrainers. Real Stories. Real Recovery.

Be supported every step of the way through this expertly designed neuroplasticity and holistic health course that is backed by science and encourages pacing, relaxation & self-care as its top priorities!

Register for our free 28-Day trial where you can watch lots of videos about how to recover, and access our Member's Area. Or if you are ready to Buy Now, click here