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Your Chronic Inflammatory Response Syndrome (CIRS) Recovery Starts Here

60% Improvement in Symptoms in CIRS participants

In our latest randomised controlled trial, participants with CIRS saw a 60% improvement in symptoms.

CIRS doesn’t always look like one illness. One day it’s crushing fatigue. The next, it’s brain fog, breathlessness, or unexplained pain. You may have seen countless doctors and still don’t have clear answers. Just know that there is hope. Thousands of people living with CIRS have found real relief through our brain retraining approach.

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Everything you need to know about Chronic Inflammatory Response Syndrome (CIRS)

Chronic Inflammatory Response Syndrome (CIRS) Symptoms
  • What Is It?

    Chronic Inflammatory Response Syndrome (CIRS) is a complex, multi-system illness triggered by exposure to biotoxins – most commonly from water-damaged buildings. It’s often misunderstood, with symptoms that span across the body and don’t always show up on standard tests. Common symptoms include:

    • Brain fog, memory problems, or poor concentration
    • Chronic fatigue or unrefreshing sleep
    • Muscle cramps, weakness, or joint pain
    • Sinus issues or shortness of breath
    • Mood swings, anxiety, or depression
    • Light, noise, or temperature sensitivity
    • Digestive issues or food intolerances
    • Hormonal imbalances or unusual weight changes
    • Increased sensitivity to mold, chemicals, or other triggers

    CIRS isn’t “just in your head” – it’s a whole-body response to a system stuck in inflammation mode.

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  • Causes of Chronic Inflammatory Response Syndrome (CIRS)
  • What Causes It?

    CIRS develops when your immune system can’t properly clear biotoxins (like mold or bacterial toxins), leading to a chronic, inflammatory cascade. But it’s not just about the exposure – it’s about the way your brain and immune system respond after the exposure.

    In many people with CIRS:

    • The innate immune system becomes dysregulated
    • Inflammation persists long after the initial trigger
    • The hypothalamic-pituitary-adrenal (HPA) axis is disrupted
    • The brain remains in a state of perceived threat
    • Energy, detox, and repair systems begin to falter

    This ongoing state of threat keeps symptoms active – even when you’ve left the exposure behind.

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  • Treatment for Chronic Inflammatory Response Syndrome (CIRS)
  • How To Reverse It?

    Most CIRS protocols focus on removing biotoxins and supporting detox. These might include:

    • Leaving or remediating moldy environments
    • Taking binders to clear toxins (e.g. cholestyramine)
    • Addressing MARCoNS, hormone imbalances, or nutrient deficits
    • Following the Shoemaker protocol
    • Reducing stress and pacing activity

    While these steps are often helpful, they may not be enough. If your brain and nervous system are still locked in a chronic threat response, healing cannot take place. 

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  • Our approach is different

    We focus on the root cause of your condition. Through brain retraining, we help shift your system out of chronic inflammation and reactivity through the power of neuroplasticity. This process:

    • Calms your brain’s overactive alarm system
    • Reduces chronic immune activation and inflammation
    • Improves tolerance to environments and stimuli
    • Supports energy production, detox, and repair
    • Helps your body regain balance and resilience

    When your brain and body feel safe again, deep healing can begin – from the inside out.

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    Recovery Stories

    Across the world, people just like you, are using the power of their brains to heal their bodies. Hear their stories, see their success, and find inspiration for your own healing journey. 

    Rediscover the Health You Deserve Today

    Start your healing journey today with our 28-day free trial - no credit card needed

    Frequently Asked Questions

    Most CIRS protocols focus on removing biotoxins and managing the downstream effects – using binders, supplements, or environmental control. While these can be helpful, they often overlook the brain’s role in keeping the inflammatory cycle going. The Gupta Program uses brain retraining to target the root of the issue: a nervous system stuck in survival mode. By calming the brain’s overactive alarm system, we help reduce chronic inflammation and restore balance – so your body can finally heal.

    If you’re experiencing symptoms like brain fog, fatigue, joint pain, sensitivity to mold or chemicals, and have a history of exposure to water-damaged buildings or other biotoxins, the Gupta Program may be right for you. It’s specifically designed for complex, multi-system conditions like CIRS, where the brain and immune system are caught in a loop of overprotection.

    Healing timelines vary from person to person. Some people notice subtle improvements within weeks, while others experience a more gradual shift. In our latest randomized controlled trial, participants with CIRS saw a 60% improvement in health and functioning after just three months. With regular practice and ongoing support, deep and lasting change is possible.

    Yes. Many people come to the Gupta Program after years – even decades – of living with CIRS. Neuroplasticity means your brain can rewire itself at any stage of life. Even longstanding inflammation patterns can shift with the right tools and consistent practice.

    Definitely. The Gupta Program is designed to complement detox protocols, medications, nutritional support, and environmental interventions. In fact, retraining the brain can often enhance your body’s ability to respond to other treatments – by lowering the stress response and improving tolerance.

    You’ll have access to everything you need to stay supported and motivated: weekly live coaching webinars, daily ‘Guptacise’ brain retraining sessions, a private online community, and guidance from experienced Coaches – many of whom have recovered from CIRS themselves. You don’t have to do this alone. We’ll walk this path with you.